بررسی تاثیر عوامل ضد اکسیدان بر سمیت کبدی 2، 3، 7، 8 تتراکلرودی بنزوپارادی اکسین ‏‎(tcdd)‎‏

Toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD).

In summary, the toxicity of TCDD has been comprehensively examined in multiple acute, subchronic, and chronic studies. Acute toxicity studies have shown marked species differences, with up to a 10,000-fold difference between the single oral LD50 dose for the guinea pig and hamster. TCDD is capable of causing an acnegenic response in man and a similar skin response in certain animals. It is also...

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27 A 3,204 bp full-length cDNA of bovine NALP9 was cloned and its genomic organisation was 28 analyzed. The 2,988 bp open reading frame covers 9 exons and encodes a deduced protein of 996 29 amino acids containing Pyrin, Nacht and leucine-rich repeat domains like the human NALP gene 30 family members. Mapping with the WGRH5000 panel and fluorescence in situ hybridisation 31 assigned NALP9 in cl...

Defending History: Temporal Reasoning in Genesis 2:7–3:8

The two groups assaulting the historicity of Genesis 2–3, whose attacks against the reality of the creation and fall of Adam and Eve have chiefly come in two guises, 1) that the text is poetry, not meant to be read historically; and 2) that it is prose meant to be read as an accurate historical record, but that it is contradictory and incoherent, are repelled by statistical, literary, and lingu...

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بررسی تاثیر تمرین هوازی تداومی بر نسبت Bax/Bcl-2 و سمیت کبدی ناشی از دوکسوروبیسین در رت‌های مدل سالمندی

Background and purpose: One of the main issues in cancer treatment is to reduce the side effects of drugs on healthy tissues. The aim of this study was to investigate the preventative effects of continuous aerobic exercise on apoptosis ratio and liver fibrosis induced by doxorubicin in aging rats. Materials and methods: In this experimental research, 42 adult Wistar rats were randomly divided ...

Peroxynitrite reaction products of 3',5'-di-O-acetyl-8-oxo-7, 8-dihydro-2'-deoxyguanosine.

Of the DNA bases, peroxynitrite (ONOO-) is most reactive toward 2'-deoxyguanosine (dGuo), but even more reactive with 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodGuo), requiring a 1,000-fold excess of dGuo to provide 50% protection against the reaction with 8-oxodGuo. Therefore, it seems reasonable that 8-oxodGuo is a potentially important target in DNA and that the structures of the reaction p...